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D4-GDI, human recombinant protein
D4-GDI, D4GDI, Rho GDP dissociation inhibitor (GDI) α
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P52565 |
|---|---|
| Concentration | 0.1 |
| Calculated MW | 54 kDa |
| Gene ID | 396 |
|---|---|
| Gene Symbol | ARHGDIA |
| Other Names | D4-GDI, D4GDI, Rho GDP dissociation inhibitor (GDI) α |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | HPLC; ≥90% |
| Recombinant | Yes |
| Format | Liquid |
| Storage | -20°C; Sterile filtered liquid (100 µg/ml) in 50mM Tris-Acetate, pH 7.5, 1mM EDTA, 20% Glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
D4-GDI belongs to the family of rho-GDI or GDP-dissociation inhibitors for the Rho/Rac family of small G proteins; consisting of rhoGDI-1, D4-GDI/rhoGDI-2 and rhoGDI-3. It inhibits the release of GDP from the Rho proteins, essential for GTP-loading and activation of GTPase activity. D4-GDI is located in the cytoplasm and is involved in the regulation of the membrane association and dissociation cycle of Rho/Rac proteins. It is known to be a substrate for caspase 3 during Fas-mediated apoptosis.
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