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Ubiquitin Aldehyde, human recombinant protein
Ubiquitin Aldehyde
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Calculated MW | 8.5 kDa |
|---|
| Other Names | Ubiquitin Aldehyde |
|---|---|
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; |
| Assay2&Purity2 | HPLC; ≥95% |
| Recombinant | Yes |
| Format | Liquid |
| Storage | -80°C. Do not lyophilize. Do not neutralize until immediately prior to use. Avoid presence of amino containing compounds.; An aqueous solution containing 0.15 M HCl |
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Provided below are standard protocols that you may find useful for product applications.
Background
The C-terminal glycine carboxyl of Ubiquitin is synthetically modified to an aldehyde. Ubiquitin Aldehyde (Ub-H) is useful in the stabilization of ubiquitin-protein conjugates in vitro, enhancing their accumulation in cell lysates and tissue extracts. Inhibition of deubiquitinylating enzyme activity by Ub-H can be used to identify and confirm such activity and to determine the inhibition kinetics for a particular enzyme. Recommended concentration for maximal inhibition is 2-5 µM. Co-crystallization of ubiquitin aldehyde with specific deubiquitinylating enzymes (the inhibitor mimics the natural ubiquitin substrate) has also been used to probe enzyme:substrate interactions.
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