Isopeptidase T (short form), human recombinant protein
USP5; Ubiquitin-specific protease 5
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P45974 |
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Concentration | 2 |
Calculated MW | 93.4 kDa |
Gene ID | 8078 |
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Gene Symbol | UBP5 |
Other Names | USP5; Ubiquitin-specific protease 5 |
Gene Source | Human |
Source | E. coli |
Assay&Purity | SDS-PAGE; ≥95% |
Assay2&Purity2 | HPLC; |
Recombinant | Yes |
Format | Liquid |
Storage | -80°C; Supplied at a concentration of 2.0 mg/ml in 50 mM Tris, 10 mM β-mercaptoethanol, pH 7.5. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Ubiquitin C-terminal hydrolases (UCHs) are a family of cysteine hydrolases that catalyze the UBPs hydrolyze isopeptide bonds between ubiquitin and the substrate protein or within polyubiquitin chains. Human isopeptidase T (isoT) is an UBP capable of binding ubiquitin that specifically disassembles free polyubiquitin chains linked through isopeptide bonds involving the K48 of ubiquitin into ubiquitin monomers.
References
Falquet L.,et al.FEBS Lett. 376:233-237(1995).
Ansari-Lari M.A.,et al.Genome Res. 6:314-326(1996).
Ansari-Lari M.A.,et al.Genome Res. 7:268-280(1997).
Tashayev V.L.,et al.Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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