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Isopeptidase T (long form), human recombinant protein
USP5; Ubiquitin-specific protease 5
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P45974 |
|---|---|
| Concentration | 0.4 |
| Calculated MW | 97.0 kDa |
| Gene ID | 8078 |
|---|---|
| Gene Symbol | UBP5 |
| Other Names | USP5; Ubiquitin-specific protease 5 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | HPLC; |
| Recombinant | Yes |
| Format | Liquid |
| Storage | -80°C; Supplied at a concentration of 0.4 mg/ml in 50 mM Tris, 10 Mmn β-mercaptoethanol, pH 7.5. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Isopeptidase T is a ubiquitin-specific processing protease (UBP) that specifically disassembles free K48-linked polyubiquitin chains into ubiquitin monomers. There are two human isopeptidase T isoforms; Isopeptidase T short form (isoT-S) and Isopeptidase T long form (isoT-L) which differ by an insertion of 23 amino acids in isoT-L. Isopeptidase T is the only UBP known to require zinc binding to be active.
References
Falquet L.,et al.FEBS Lett. 376:233-237(1995).
Ansari-Lari M.A.,et al.Genome Res. 6:314-326(1996).
Ansari-Lari M.A.,et al.Genome Res. 7:268-280(1997).
Tashayev V.L.,et al.Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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