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Angiotensin II recombinant protein
Angiotensin, Angiotensin II
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P01019 |
|---|---|
| Calculated MW | 52070 Da |
| Gene ID | 183 |
|---|---|
| Gene Symbol | ANGT |
| Other Names | Angiotensin, Angiotensin II |
| Gene Source | Human |
| Assay&Purity | SDS-PAGE; |
| Assay2&Purity2 | HPLC; ≥95% |
| Recombinant | Yes |
| Application Notes | H₂O |
| Format | Lyophilized protein |
| Storage | -20°C; Lyophilized powder |
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Provided below are standard protocols that you may find useful for product applications.
Background
The octapeptide angiotensin II exerts a wide range of effects on the cardioVascular system. It is also implicated in the regulation of cell proliferation, fibrosis and apoptosis. Angiotensin II is formed by cleavage of angiotensin I by angiotensin-converting enzyme (ACE) or chymases. Human heart chymase, a chymotrypsin-like serine proteinase, hydrolyzes the Phe8-His9 bond to yield the octapeptide hormone angiotensin II and His-Leu.
References
Kageyama R.,et al.Biochemistry 23:3603-3609(1984).
Gaillard I.,et al.DNA 8:87-99(1989).
Fukamizu A.,et al.J. Biol. Chem. 265:7576-7582(1990).
Kunapuli S.P.,et al.Circ. Res. 60:786-790(1987).
Kunapuli S.P.,et al.Arch. Biochem. Biophys. 254:642-646(1987).
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