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Angiostatin Human recombinant protein
Angiostatin K1-4, Angiostatin Kringles 1-4
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Concentration | 7.0-8.0 |
|---|---|
| Calculated MW | 50.0 kDa |
| Other Names | Angiostatin K1-4, Angiostatin Kringles 1-4, plasminogen |
|---|---|
| Gene Source | Human |
| Source | Human Plasma |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | HPLC; |
| Recombinant | No |
| Format | Liquid |
| Storage | -80°C; In 20 mM HEPES, 150 mM NaCl, pH 7.4 |
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Provided below are standard protocols that you may find useful for product applications.
Background
Angiostatin is a proteolytic fragment of plasminogen constituting kringles 1 - 4. It is a potent angiogenesis inhibitor and the inhibition of angiogenesis by angiostatin is directly related to inhibiting the proliferation of endothelial cells. Human Angiostatin significantly inhibits bFGF-induced endothelial cell proliferation and migration at concentrations ranging from 300 nM – 1.0 µM.
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