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Angiostatin K1-3, human recombinant protein
Angiostatin K1-3, Angiostatin Kringles 1-3
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P00747 |
|---|---|
| Calculated MW | 30.0 kDa |
| Other Names | Angiostatin K1-4, Angiostatin Kringles 1-4, plasminogen |
|---|---|
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | HPLC; ≥95% |
| Recombinant | Yes |
| Results | 0.55×10⁵ Units/mg. |
| Application Notes | Reconstitute in sterile distilled H₂O or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. |
| Format | Lyophilized protein |
| Storage | -20°C; From 20 mM Sodium Acetate, pH 5.5, 4% mannitol |
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Provided below are standard protocols that you may find useful for product applications.
Background
Ang K1-3 is a single, non-glycosylated polypeptide chain containing 259 amino acids. It represents a proteolytic fragment of plasminogen containing the first three kringle structures. A specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED₅₀ =70 nM) relative to kringles 1-4 (ED₅₀ = 135 nM). Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth.
References
Petersen T.E.,et al.J. Biol. Chem. 265:6104-6111(1990).
Forsgren M.,et al.FEBS Lett. 213:254-260(1987).
Browne M.J.,et al.Submitted (OCT-1991) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Sottrup-Jensen L.,et al.Submitted (JUL-1977) to the PIR data bank.
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