BMP-3 Blocking Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P12645 |
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Gene ID | 651 |
Calculated MW | 53372 Da |
Gene ID | 651 |
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Application & Usage | The peptide is used for blocking the antibody activity of BMP-3. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37°C. |
Other Names | Bone morphogenetic protein 3, BMP-3, Bone morphogenetic protein 3A, BMP-3A, Osteogenin, BMP3, BMP3A |
Target/Specificity | BMP-3 |
Formulation | 50 µg (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | BMP-3 Blocking Peptide is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BMP3 |
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Synonyms | BMP3A |
Function | Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and ossification (PubMed:11138004, PubMed:15269709). Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways (PubMed:31665064). |
Cellular Location | Secreted. |
Tissue Location | Expressed in adult and fetal cartilage. |
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