|Calculated MW||30.3 kDa (19-256 aa + N-terminal poly-his tag)|
|Other Names||GHR, GHBP, GH receptor, Somatotropin receptor, Serum-binding protein|
|Application Notes||Reconstitute in sterile dH₂O not less than 100 µg/ml. This solution can then be diluted into other aqueous buffers|
|Storage||-20°C; GHBP was lyophilized from a concentrated (1 mg/ml) solution with 0.0045 mM NaHCO₃.|
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Provided below are standard protocols that you may find useful for product applications.
GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and interCellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28.1 kDa. GHBP is purified by proprietary chromatographic techniques.
Leung D.W.,et al.Nature 330:537-543(1987).
Godowski P.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:8083-8087(1989).
Urbanek M.,et al.Mol. Endocrinol. 6:279-287(1992).
Dastot F.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:10723-10728(1996).
Amit T.,et al.J. Clin. Endocrinol. Metab. 82:3813-3817(1997).
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