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GHBP, human recombinant protein
GHR, GHBP, GH receptor, Somatotropin receptor
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P10912 |
|---|---|
| Calculated MW | 30.3 kDa (19-256 aa + N-terminal poly-his tag) |
| Gene ID | 2690 |
|---|---|
| Gene Symbol | GHR |
| Other Names | GHR, GHBP, GH receptor, Somatotropin receptor, Serum-binding protein |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | HPLC; ≥95% |
| Recombinant | Yes |
| Application Notes | Reconstitute in sterile dH₂O not less than 100 µg/ml. This solution can then be diluted into other aqueous buffers |
| Format | Lyophilized protein |
| Storage | -20°C; GHBP was lyophilized from a concentrated (1 mg/ml) solution with 0.0045 mM NaHCO₃. |
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Provided below are standard protocols that you may find useful for product applications.
Background
GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and interCellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28.1 kDa. GHBP is purified by proprietary chromatographic techniques.
References
Leung D.W.,et al.Nature 330:537-543(1987).
Godowski P.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:8083-8087(1989).
Urbanek M.,et al.Mol. Endocrinol. 6:279-287(1992).
Dastot F.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:10723-10728(1996).
Amit T.,et al.J. Clin. Endocrinol. Metab. 82:3813-3817(1997).
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