|Calculated MW||15.7 kDa|
|Other Names||Interleukin 31, IL31|
|Sequence||MTCSLSFGAP ISKEDLRTTI DLLKQESQDL YNNYSIKQAS GMSADESIQL PCFSLDREAL TNISVIIAHL EKVKVLSENT VDTSWVIRWL TNISCFNPLN LNISVPGNTD ESYDCKVFVL TVLKQFSNCM AELQAKDNTT C|
|Application Notes||Reconstitute in sterile H₂O at a concentration of 0.1mg/ml. It is recommended that a carrier protein (0.1% HSA or BSA) is added for long term storage. Reconstituted IL-31 should be stored in working aliquots at -20°C.|
|Storage||-20°C; Sterile filtered white powder lyophilized from a solution containing 10 mM sodium phosphate buffer pH 7.5.|
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Provided below are standard protocols that you may find useful for product applications.
Interleukin-31 (IL-31) is an immunoregulatory cytokine that is mainly expressed by activated TH2 cells. IL-31 signals through the IL-31 Receptor (IL-31RA) and the oncostain receptor (OSMR), which are expressed on monocytes, epithelial cells, and keratinocytes. IL-31 has a role in inflammatory skin diseases. Recombinant mouse IL-31 is a non-glycosylated protein, containing 141 amino acids, with a mass of 15.7 kDa.
Dillon S.R.,et al.Nat. Immunol. 5:752-760(2004).
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