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Human Ghrelin recombinant protein
Human Ghrelin (Ser3 modified), Ghrelin, h-Ghrelin, rh-Ghrelin, recombinant human Ghrelin, Ghrelin (S
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UBU3 |
|---|---|
| Calculated MW | 3.374 kDa |
| Gene ID | 51738 |
|---|---|
| Gene Symbol | GHRL |
| Other Names | Appetite-regulating hormone, Growth hormone secretagogue, Growth hormone-releasing peptide, Motilin-related peptide, Protein M46Human Ghrelin (Ser3 modified), Ghrelin, h-Ghrelin, rh-Ghrelin, recombinant human Ghrelin, Ghrelin (Ser3 modified), recombinant Ghrelin, Ghrelin |
| Gene Source | Human |
| Assay&Purity | SDS-PAGE; |
| Assay2&Purity2 | HPLC; |
| Recombinant | No |
| Sequence | GS(X)FLSPEHQRVQQRKESKKPPAKLQPR X = serine modified with n-octanoic acid |
| Application Notes | Reconstitute in PBS containing at least 0.1% BSA to a concentration of 1.0 mg/ml. |
| Format | Lyophilized peptide |
| Storage | -20°C; Lyophilized peptide |
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Provided below are standard protocols that you may find useful for product applications.
Background
Ghrelin (‘ghre’ is the Proto-Indo-European root of the word ‘grow’) has been identified as the endogenous ligand for the GHS-R (growth hormone secretagogues receptor). Ghrelin is expressed in the stomach, small and large intestines, and brain regions that are involved in the regulation of food intake. Both ghrelin and GHS-R expression is also detected in the heart, suggesting that Ghrelin might have some cardiovascular effects. Ghrelin administration stimulates GH secretion but also causes weight gain by increase food intake. Mature human and rat Ghrelin (28 a.a.) are produced from a 117 amino acid precursor. Ghrelin has an unusual modification at Ser3 residue that is n-octanoylated and is essential for biological activity. Ghrelin is the first known example of a bioactive peptide modified by an acyl acid
References
Kojima M.,et al.Nature 402:656-660(1999).
Tomasetto C.,et al.Gastroenterology 119:395-405(2000).
Wajnrajch M.P.,et al.J. Endocr. Genet. 1:231-233(2000).
Hosoda H.,et al.J. Biol. Chem. 278:64-70(2003).
Seim I.,et al.BMC Genomics 8:298-298(2007).
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