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Human CellExp Renin, Human recombinant protein
Human Recombinant HIS-tagged Renin
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P00797 |
|---|---|
| Concentration | 0.74 |
| Calculated MW | 40 kDa (contains 8x HIS tag at the CT) |
| Gene ID | 5972 |
|---|---|
| Gene Symbol | REN |
| Other Names | Angiotensinogenase, REN. |
| Gene Source | Human |
| Source | Human Embryonic Kidney (HEK) cells |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Format | Liquid |
| Storage | -80°C; 0.74 mg/ml solution in 0.05M Tris-HCl and 0.05 M NaCl, pH 8.0 |
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Provided below are standard protocols that you may find useful for product applications.
Background
Renin is an aspartyl protease that is specific for only one substrate, angiotensinogen. Prorenin is a glycosylated aspartic protease that consists of 2 homologous lobes and is the precursor of renin. Prorenin exhibits a low level of enzymatic activity relative to renin. BioVision’s human renin is produced from the proenzyme prorenin by proteolytic cleavage of a 43 amino acid N-terminal prosegment using limited enzymatic digestion by immobilized trypsin and purified by affinity chromatography. Conversion to active renin is >99.99 percent.
References
Imai T.,et al.Proc. Natl. Acad. Sci. U.S.A. 80:7405-7409(1983).
Morris B.J.,et al.Clin. Sci. 71:345-355(1986).
Hardman J.A.,et al.DNA 3:457-468(1984).
Rieder M.J.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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