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Human recombinant protein FKBP2
Human Recombinant FKBP2
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P26885 |
|---|---|
| Concentration | 1 |
| Calculated MW | 13.4 kDa (122 aa, 22-142 aa) |
| Gene ID | 2286 |
|---|---|
| Gene Symbol | FKBP2 |
| Other Names | Peptidyl-prolyl cis-trans isomerase FKBP2, FKBP-13, PPIase |
| Gene Source | Human |
| Source | E. Coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Sequence | MATGAEGKRK LQIGVKKRVD HCPIKSRKGD VLHMHYTGKL EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE KRKLVIPSEL GYGERGAPPK IPGGATLVFE VELLKIERRT EL |
| Format | Liquid |
| Storage | -80°C; 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 10% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
FKBP2 is part of the immunophilin protein family, which takes part in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP2 is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. FKBP2 functions as an ER chaperone and as a component of membrane cytoskeletal scaffolds.
References
Jin Y.-J.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:6677-6681(1991).
Dilella A.G.,et al.Biochem. Biophys. Res. Commun. 189:819-823(1992).
Padilla P.I.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:2322-2327(2003).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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