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Human recombinant protein TNF-beta/LTA
Human Recombinant TNF-beta/LTA
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P01374 |
|---|---|
| Concentration | 0.5 |
| Calculated MW | 20.9 kDa (192 aa, 35-205 aa + His-Tag) |
| Gene ID | 4049 |
|---|---|
| Gene Symbol | LTA |
| Other Names | Lymphotoxin alpha, LT, TNFB, TNFSF1. |
| Gene Source | Human |
| Source | E. Coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | <0.3 ng/ml |
| Sequence | MGSSHHHHHH SSGLVPRGSH MLPGVGLTPS AAQTARQHPK MHLAHSTLKP AAHLIGDPSK QNSLLWRANT DRAFLQDGFS LSNNSLLVPT SGIYFVYSQV VFSGKAYSPK ATSSPLYLAH EVQLFSSQYP FHVPLLSSQK MVYPGLQEPW LHSMYHGAAF QLTQGDQLST HTDGIPHLVL SPSTVFFGAF AL |
| Format | Liquid |
| Storage | -80°C; 0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TNF-beta, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. It is highly inducible, secreted, and exists as homotrimeric molecule. It forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. It mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. It is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.
References
Nedospasov S.A.,et al.Cold Spring Harb. Symp. Quant. Biol. 51:611-624(1986).
Nedwin G.E.,et al.J. Cell. Biochem. 29:171-181(1985).
Kobayashi Y.,et al.J. Biochem. 100:727-733(1986).
Gray P.W.,et al.Nature 312:721-724(1984).
Matsuyama N.,et al.FEBS Lett. 302:141-144(1992).
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