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Human recombinant protein SORD
Human Recombinant SORD
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q00796 |
|---|---|
| Concentration | 0.5 |
| Calculated MW | 40.4 kDa (377 aa, 1-357 aa + NT His Tag) |
| Gene ID | 6652 |
|---|---|
| Gene Symbol | SORD |
| Other Names | Sorbitol dehydrogenase |
| Gene Source | Human |
| Source | E. Coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | >0.2 units/mg |
| Sequence | MGSSHHHHHH SSGLVPRGSH MAAAAKPNNL SLVVHGPGDL RLENYPIPEP GPNEVLLRMH SVGICGSDVH YWEYGRIGNF IVKKPMVLGH EASGTVEKVG SSVKHLKPGD RVAIEPGAPR ENDEFCKMGR YNLSPSIFFC ATPPDDGNLC RFYKHNAAFC YKLPDNVTFE EGALIEPLSV GIHACRRGGV TLGHKVLVCG AGPIGMVTLL VAKAMGAAQV VVTDLSATRL SKAKEIGADL VLQISKESPQ EIARKVEGQL GCKPEVTIEC TGAEASIQAG IYATRSGGTL VLVGLGSEMT TVPLLHAAIR EVDIKGVFRY CNTWPVAISM LASKSVNVKP LVTHRFPLEK ALEAFETFKK GLGLKIMLKC DPSDQNP |
| Format | Liquid |
| Storage | -80°C; 0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 5 mM DTT and 20% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SORD, also known as L-iditol 2-dehydrogenase or SORD1, is a 357 amino acid member of the zinc containing alcohol dehydrogenase family. It is widely expressed with highest expression in kidney and in the lens of the eye. SORD enzymatically catalyzes the zinc-dependent interconversion of polyols, such as sorbitol and xylitol, to their respective ketoses.
References
Lee F.K.,et al.Genomics 21:354-358(1994).
Iwata T.,et al.Genomics 26:55-62(1995).
Carr I.M.,et al.Eur. J. Biochem. 245:760-767(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
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