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Human recombinant protein ADA
Human Recombinant ADA
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P00813 |
|---|---|
| Concentration | 0.5 |
| Calculated MW | 42.9 kDa (383 aa, 1-363 aa + NT His Tag) |
| Gene ID | 100 |
|---|---|
| Gene Symbol | ADA |
| Other Names | Adenosine deaminase, Adenosine aminohydrolase, ADA1. |
| Gene Source | Human |
| Source | E. Coli |
| Assay&Purity | SDS-PAGE; ≥85% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | >25 units/mg |
| Sequence | MGSSHHHHHH SSGLVPRGSH MAQTPAFDKP KVELHVHLDG SIKPETILYY GRRRGIALPA NTAEGLLNVI GMDKPLTLPD FLAKFDYYMP AIAGCREAIK RIAYEFVEMK AKEGVVYVEV RYSPHLLANS KVEPIPWNQA EGDLTPDEVV ALVGQGLQEG ERDFGVKARS ILCCMRHQPN WSPKVVELCK KYQQQTVVAI DLAGDETIPG SSLLPGHVQA YQEAVKSGIH RTVHAGEVGS AEVVKEAVDI LKTERLGHGY HTLEDQALYN RLRQENMHFE ICPWSSYLTG AWKPDTEHAV IRLKNDQANY SLNTDDPLIF KSTLDTDYQM TKRDMGFTEE EFKRLNINAA KSSFLPEDEK RELLDLLYKA YGMPPSASAG QNL |
| Format | Liquid |
| Storage | -80°C; 0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 20% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ADA, also known as adenosine deaminase, catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. This protein plays an important role in purine metabolism and in adenosine homeostasis. ADA acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte epithelial cell adhesion.
References
Daddona P.E.,et al.J. Biol. Chem. 259:12101-12106(1984).
Wiginton D.A.,et al.Nucleic Acids Res. 12:2439-2446(1984).
Valerio D.,et al.EMBO J. 4:437-443(1985).
Wiginton D.A.,et al.Biochemistry 25:8234-8244(1986).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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