IL-36γ, Human recombinant protein
IL-1F, IL-1ε (epsilon), IL-1F9, IL-1H1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NZH8 |
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Calculated MW | 17.0 kDa |
Gene ID | 56300 |
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Gene Symbol | IL36G |
Other Names | IL-1F, IL-1ε (epsilon), IL-1F9, IL-1H1 |
Gene Source | Human |
Source | E.coli |
Assay&Purity | SDS-PAGE; ≥98% |
Assay2&Purity2 | HPLC; |
Recombinant | Yes |
Sequence | SMCKPITGTI NDLNQQVWTL QGQNLVAVPR SDSVTPVTVA VITCKYPEAL EQGRGDPIYL GIQNPEMCLY CEKVGEQPTL QLKEQKIMDL YGQPEPVKPF LFYRAKTGRT STLESVAFPD WFIASSKRDQ PIILTSELGK SYNTAFELNI ND |
Target/Specificity | IL-36γ |
Application Notes | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. |
Format | Lyophilized powder |
Storage | -20°C; Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium Phosphate, pH 7.0 and 50 mM NaCl. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36γ is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36γ signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36γ also functions as an agonist of NF-kappaB, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant human IL-36γ is a 17.0 kDa protein containing 152 amino acid residues.
References
Kumar S.,et al.J. Biol. Chem. 275:10308-10314(2000).
Debets R.,et al.J. Immunol. 167:1440-1446(2001).
Busfield S.J.,et al.Genomics 66:213-216(2000).
Nicklin M.J.H.,et al.Genomics 79:718-725(2002).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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