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UPK3A, human recombinant protein
Uroplakin 3A, UPK3, UPIII, Uroplakin III, UP3A
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O75631 |
|---|---|
| Calculated MW | 23.1 kDa |
| Gene ID | 7380 |
|---|---|
| Gene Symbol | UPK3A |
| Other Names | Uroplakin 3A, UPK3, UPIII, Uroplakin III, UP3A |
| Gene Source | Human |
| Source | E. Coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | HPLC; |
| Recombinant | Yes |
| Sequence | MGSSHHHHHH SSGLVPRGSH MGSHMVNLQP QLASVTFATN NPTLTTVALE KPLCMFDSKE ALTGTHEVYL YVLVDSAISR NASVQDSTNT PLGSTFLQTE GGRTGPYKAV AFDLIPCSDL PSLDAIGDVS KASQILNAYL VRVGANGTCL WDPNFQGLCN PPLSAATEYR FKYVLVNMST GLVEDQTLWS DPIRTNQLTP YSTIDTWPGR RSGG |
| Target/Specificity | UPK3A |
| Format | Liquid |
| Storage | -20°C; Sterile filtered colorless solution of 0.25 mg/ml containing 20 mM Tris-HCl buffer (pH 8.0), 150 mM NaCl, 2 mM DTT and 20% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
UPK3A is a member of the uroplakin-3 family. Uroplakins (UP) which are transmembrane proteins are important components of the urothelium that pass the lipid bilayer once (UPII, UPIIIa, and UPIIIb) or four times (UPIa and UPIb; both members of the "tetraspanin" family). All hold great luminal/extracellular domains, but only UPIIIa and UPIIIb have significant cytoplasmic shares in their C-termini. UPK3A is an extremely specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. Alterations in this gene are related to renal adysplasia.
References
Geall K.,et al.Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
Yuasa T.,et al.Jpn. J. Cancer Res. 89:879-882(1998).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Dunham I.,et al.Nature 402:489-495(1999).
Lobban E.D.,et al.Am. J. Pathol. 153:1957-1967(1998).
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