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Thymosin-β4, human recombinant protein
Tβ-4, Hematopoietic system regulatory peptide, Seraspenide, TMSB4X, TB4X, TMSB4
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P62328 |
|---|---|
| Calculated MW | 5.2 kDa |
| Gene ID | 7114 |
|---|---|
| Gene Symbol | TMSB4X |
| Other Names | Tβ-4, Hematopoietic system regulatory peptide, Seraspenide, TMSB4X, TB4X, TMSB4 |
| Gene Source | Human |
| Source | E. Coli |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | HPLC; |
| Recombinant | Yes |
| Sequence | RMSDKPDMAE IEKFDKSKLK KTETQEKNPL PSKETIEQEK QAGES |
| Target/Specificity | Thymosin-β4 |
| Application Notes | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. |
| Format | Lyophilized powder |
| Storage | -20°C; Sterile filtered through a 0.2 micron filter. Lyophilized with no additives |
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Provided below are standard protocols that you may find useful for product applications.
Background
Thymosin-β4 is a small, actin-sequestering protein belonging to the thymosin-β family that is found at high concentrations within the spleen, thymus, and peritoneal macrophages, where it is most notably responsible for the organization of cytoskeletal structure. In mammalian tissues, this protein acts as a modulator for the polymerization/depolymerization of actin through the formation of a 1:1 complex with the monomer G (globular)-actin, and inhibits actin’s polymerization to form F (filamentous) actin, which together with other proteins binds microfilaments to construct the cytoskeleton. Commonly found at significant quantities within the brain, lungs, liver, kidneys, testes, and heart, Thymosin-β4 has also been shown to be synthesized by cells unrelated to the reticulo-endothelial system, such as myoblasts and fibroblasts, and expressed at irregular levels by several hemopoietic cell lines, malignant lymphoid cells and myeloma cells. In addition to regulating actin polymerization, research has also found Thymosin-β4 to stimulate the secretion of hypothalamic luteinizing hormone-releasing hormone and luteinizing hormone, inhibit the migration of peritoneal macrophages, induce phenotypic changes in T cell lines during early host defense mechanisms, and inhibit the progression of hematopoietic pluripotent stem cells into the s-phase. Recombinant Human Thymosin-β4 is a 5.2 kDa glycoprotein containing 45 amino acid residues.
References
Gondo H.,et al.J. Immunol. 139:3840-3848(1987).
Yang S.P.,et al.Mol. Cell. Biochem. 272:97-105(2005).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Safer D.,et al.J. Biol. Chem. 266:4029-4032(1991).
Friedman R.L.,et al.Cell 38:745-755(1984).
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