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CD226, human recombinant protein
CD226 antigen, DNAM-1, DNAM1, PTA1, TLiSA1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15762 |
|---|---|
| Concentration | 1 |
| Calculated MW | 29.4 kDa (259 aa, 19-254 aa + His tag), confirmed by MALDI-TOF. |
| Gene ID | 10666 |
|---|---|
| Gene Symbol | CD226 |
| Other Names | CD226 antigen, DNAM-1, DNAM1, PTA1, TLiSA1 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Sequence | MGSSHHHHHH SSGLVPRGSH MGSEEVLWHT SVPFAENMSL ECVYPSMGIL TQVEWFKIGT QQDSIAIFSP THGMVIRKPY AERVYFLNST MASNNMTLFF RNASEDDVGY YSCSLYTYPQ GTWQKVIQVV QSDSFEAAVP SNSHIVSEPG KNVTLTCQPQ MTWPVQAVRW EKIQPRQIDL LTYCNLVHGR NFTSKFPRQI VSNCSHGRWS VIVIPDVTVS DSGLYRCYLQ ASAGENETFV MRLTVAEGKT DNQYTLFVA |
| Target/Specificity | CD226 |
| Format | Liquid |
| Storage | -80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CD226 is a 65 kDa glycoprotein expressed on the surface NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. CD226 mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. This protein also plays a role in megakaryocytic cell maturation. Recombinant human CD226 protein, fused to His-tag at N-terminus, was expressed in E.coli.
References
Shibuya A.,et al.Immunity 4:573-581(1996).
Biassoni R.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 437:551-555(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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