TNFRSF6B, human recombinant protein
Tumor necrosis factor receptor superfamily member 6B
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O95407 |
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Concentration | 1 |
Calculated MW | 32.1 kDa (294 aa, 30-300 aa + His Tag), confirmed by MALDI-TOF. |
Gene ID | 8771 |
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Gene Symbol | TNFRSF6B |
Other Names | Tumor necrosis factor receptor superfamily member 6B |
Gene Source | Human |
Source | E. coli |
Assay&Purity | SDS-PAGE; ≥85% |
Assay2&Purity2 | N/A; |
Recombinant | Yes |
Sequence | MGSSHHHHHH SSGLVPRGSH MGSVAETPTY PWRDAETGER LVCAQCPPGT FVQRPCRRDS PTTCGPCPPR HYTQFWNYLE RCRYCNVLCG EREEEARACH ATHNRACRCR TGFFAHAGFC LEHASCPPGA GVIAPGTPSQ NTQCQPCPPG TFSASSSSSE QCQPHRNCTA LGLALNVPGS SSHDTLCTSC TGFPLSTRVP GAEECERAVI DFVAFQDISI KRLQRLLQAL EAPEGWGPTP RAGRAALQLK LRRRLTELLG AQDGALLVRL LQALRVARMP GLERSVRERF LPVH |
Target/Specificity | TNFRSF6B |
Format | Liquid |
Storage | -80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol and 2 M Urea |
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Background
TNFRSF6B belongs to Tumor necrosis factor receptor superfamily. It acts as a decoy receptor that competes with death receptors for ligand binding. This protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A. Recombinant human TNFRSF6B protein, fused to His-tag at N-terminus, was expressed in E.coli.
References
Pitti R.M.,et al.Nature 396:699-703(1998).
Yu K.-Y.,et al.J. Biol. Chem. 274:13733-13736(1999).
Bai C.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:1230-1235(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Deloukas P.,et al.Nature 414:865-871(2001).
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