IGF-BP6, human recombinant protein
Insulin-like growth factor-binding protein 6, IBP6
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P24592 |
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Concentration | 0.5 |
Calculated MW | 25 kDa (236 aa, 28-240 aa + His Tag), confirmed by MALDI-TOF. |
Gene ID | 3489 |
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Gene Symbol | IGFBP6 |
Other Names | Insulin-like growth factor-binding protein 6, IBP6 |
Gene Source | Human |
Source | E. coli |
Assay&Purity | SDS-PAGE; ≥85% |
Assay2&Purity2 | N/A; |
Recombinant | Yes |
Sequence | MGSSHHHHHH SSGLVPRGSH MGSRCPGCGQ GVQAGCPGGC VEEEDGGSPA EGCAEAEGCL RREGQECGVY TPNCAPGLQC HPPKDDEAPL RALLLGRGRC LPARAPAVAE ENPKESKPQA GTARPQDVNR RDQQRNPGTS TTPSQPNSAG VQDTEMGPCR RHLDSVLQQL QTEVYRGAQT LYVPNCDHRG FYRKRQCRSS QGQRRGPCWC VDRMGKSLPG SPDGNGSSSC PTGSSG |
Target/Specificity | IGFBP6 |
Format | Liquid |
Storage | -80°C; 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 1 mM DTT and 20% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
IGFBP6 contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Recombinant human IGFPB6 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
References
Kiefer M.C.,et al.J. Biol. Chem. 266:9043-9049(1991).
Ehrenborg E.,et al.Mamm. Genome 10:376-380(1999).
Shimasaki S.,et al.Mol. Endocrinol. 5:938-948(1991).
Zapf J.,et al.J. Biol. Chem. 265:14892-14898(1990).
Roghani M.,et al.FEBS Lett. 255:253-258(1989).
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