FNDC5, human/mouse recombinant protein
Fibronectin Type III Domain-containing Protein 5; Fibronectin Type III Repeat-containing Protein 2
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8NAU1 |
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Calculated MW | ~16.0 kDa. (extracellular domain, human (aa 32-152) / mouse (aa 29-149)) is untagged. FNDC5 extracellular domain has 100% identity between human, mouse and rat. |
Gene ID | 252995 |
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Gene Symbol | FNDC5 |
Other Names | Fibronectin Type III Domain-containing Protein 5; Fibronectin Type III Repeat-containing Protein 2 |
Gene Source | Human/Mouse |
Source | E. coli |
Assay&Purity | SDS-PAGE; ≥95% |
Assay2&Purity2 | N/A; |
Recombinant | Yes |
Target/Specificity | FNDC5 |
Application Notes | Reconstitute with 100 µl sterile distilled water. |
Format | Lyophilized |
Storage | -20°C; Lyophilized in PBS. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Bostrom P.,et al.Nature 481:463-468(2012).
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