BAZ2B bromodomain (2064-2168 aa) (GST-tagged), Human recombinant protein
BAZ2B bromodomain (2064-2168 aa) (GST-tagged), Human recombinant
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UIF8 |
---|---|
Calculated MW | 40.2 kDa (2064-2168 aa + NT GST Tag) |
Gene ID | 29994 |
---|---|
Gene Symbol | BAZ2B |
Other Names | Bromodomain Adjacent to Zinc Finger Domain 2B; KIAA1476; WALp4 |
Gene Source | Human |
Source | E. coli |
Assay&Purity | SDS-PAGE; ≥80% |
Assay2&Purity2 | HPLC; |
Recombinant | Yes |
Target/Specificity | BAZ2B |
Format | Liquid |
Storage | -80°C; 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BAZ2B is expressed in heart, skeletal, testis, and pancreatic tissues. A rare allele of BAZ2B has been identified to be a predictor of Sudden Cardiac Death.4 The full-length protein contains several DNA-targeting domains, including a methyl-CpG binding domain, a DNA-binding DDT domain, and a tandem PHD-bromodomain. This protein product contains the bromodomain of BAZ2B.
References
Jones M.H.,et al.Genomics 63:40-45(2000).
Nagase T.,et al.DNA Res. 7:143-150(2000).
Ohara O.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.