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Guanylate kinase, human recombinant
GMK, GMP kinase, Guanylate kinase
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q16774 |
|---|---|
| Concentration | 1 mg/ml |
| Calculated MW | 23.9 kDa |
| Gene ID | 2987 |
|---|---|
| Other Names | GMK, GMP kinase, Guanylate kinase |
| Gene Source | Human |
| Source | E. Coli |
| Assay&Purity | SDS-PAGE;≥90% |
| Recombinant | Yes |
| Sequence | MGSSHHHHHH SSGLVPRGSH MSGPRPVVLS GPSGAGKSTL LKRLLQEHSG IFGFSVSHTT RNPRPGEENG KDYYFVTREV MQRDIAAGDF IEHAEFSGNL YGTSKVAVQA VQAMNRICVL DVDLQGVRNI KATDLRPIYI SVQPPSLHVL EQRLRQRNTE TEESLVKRLA AAQADMESSK EPGLFDVVII NDSLDQAYAE LKEALSEEIK KAQRTGA |
| Target/Specificity | GUK1 |
| Format | Liquid |
| Storage | -20°C;In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 1mM DTT, 0.1M NaCl |
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Provided below are standard protocols that you may find useful for product applications.
Background
GUK1, also known as GMK, belongs to the guanylate kinase family. This protein exists as a monomer that catalyzes the ATP-dependent conversion of GMP to GDP, thereby playing an essential role in the recycling of GMP. Via its catalytic activity, GUK1 is thought to participate in regulating the supply of guanine nucleotides to signal transduction pathways. Overexpression of GUK1 is associated with pituitary adenocarcinomas, suggesting that GUK1 is involved in tumorigenesis. Recombinant human GUK1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
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