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Human CellExp™ Her2/ErbB2, Extracellular Domain (ED), Human Recombinant
erbB-2, MNL 19, CD340, Neu, c-ErbB-2, NEU, NGL, TKR1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P04626 |
|---|---|
| Calculated MW | 70.6 kDa |
| Gene ID | 2064 |
|---|---|
| Other Names | erbB-2, MNL 19, CD340, Neu, c-ErbB-2, NEU, NGL, TKR1 |
| Gene Source | Human |
| Source | HEK 293 cells |
| Assay&Purity | SDS-PAGE;> 95% |
| Recombinant | Yes |
| Target/Specificity | ERBB2 |
| Application Notes | Reconstitute in sterile deionized water to a concentration up to 0.2 mg/ml. |
| Format | Lyophilized |
| Storage | -20°C;Lyophilized from 0.22 µm filtered solution in PBS pH 7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2, HER-2 /neu, NEU, NGL, TKR1 and c-erb B2, and is a protein involved in higher aggressiveness of breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation.
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