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IL-1RA
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P18510 |
|---|---|
| Species | Human |
| Sequence | Arg26-Glu177 |
| Purity | > 96% as analyzed by SDS-PAGE > 96% as analyzed by HPLC |
| Endotoxin Level | < 1 EU/ µg of protein by LAL method |
| Biological Activity | Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1α-dependent proliferation of murine D10S cells is less than 40.0 ng/ml, corresponding to a specific activity of > 2.5 × 104 IU/mg in the presence of 50.0 pg/ml rHuIL-1α. |
| Expression System | E. coli |
| Theoretical Molecular Weight | 17.1 kDa |
| Formulation | Lyophilized from a 0.2 µm filtered solution in PBS, pH 7.4. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
| Gene ID | 3557 |
|---|---|
| Other Names | Interleukin-1 receptor antagonist protein, IL-1RN, IL-1ra, IRAP, ICIL-1RA, IL1 inhibitor, Anakinra, IL1RN, IL1F3, IL1RA |
| Target Background | Interleukin-1 receptor antagonist (IL-1ra) is a member of the IL-1 family. Endogenous IL-1ra is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL1-ra. The regulated expression of IL1ra in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts the synthesis of IL-1ra is markedly enhanced by IL-1 , TNF-alpha , or PDGF. |
| Name | IL1RN |
|---|---|
| Synonyms | IL1F3, IL1RA |
| Function | Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens. |
| Cellular Location | [Isoform 1]: Secreted [Isoform 3]: Cytoplasm. |
| Tissue Location | The intracellular form of IL1RN is predominantly expressed in epithelial cells |
Research Areas
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Cat# PVGS1029
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