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BD-4
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8WTQ1 |
|---|---|
| Species | Human |
| Sequence | Glu23-Pro72 |
| Purity | > 98% as analyzed by SDS-PAGE > 98% as analyzed by HPLC |
| Endotoxin Level | < 1 EU/ µg of protein by LAL method |
| Biological Activity | Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 0.1-100.0 ng/ml. |
| Expression System | E. coli |
| Theoretical Molecular Weight | 6.0 kDa |
| Formulation | Lyophilized from a 0.2 µm filtered solution in 20 mM PBS, pH 7.4, 130 mM NaCl. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
| Gene ID | 140596;503618 |
|---|---|
| Other Names | Beta-defensin 104, Beta-defensin 4, BD-4, DEFB-4, hBD-4, Defensin, beta 104, DEFB104A, DEFB104, DEFB4 |
| Target Background | Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four human β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. BD-4 is expressed in testis, stomach, uterus, neutrophils, thyroid, lung and kidney. In addition to its direct antimicrobial activities, BD-4 is chemoattractant towards human blood monocytes. |
| Name | DEFB104A |
|---|---|
| Synonyms | DEFB104, DEFB4 |
| Function | Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103. |
| Cellular Location | Secreted. |
| Tissue Location | High expression in the testis. Gastric antrum exhibited relatively high levels. A lower expression is observed in uterus and neutrophils thyroid gland, lung, and kidney. No detectable expression in other tissues tested. |
Research Areas
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Cat# PVGS1045
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