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MDC/CCL22
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O88430 |
|---|---|
| Species | Mouse |
| Sequence | Gly25-Ser92 |
| Purity | > 97% as analyzed by SDS-PAGE > 97% as analyzed by HPLC |
| Endotoxin Level | < 1 EU/ µg of protein by LAL method |
| Biological Activity | Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human activated lymphocytes is in a concentration range of 10.0-100.0 ng/ml. |
| Expression System | E. coli |
| Theoretical Molecular Weight | 7.8 kDa |
| Formulation | Lyophilized from a 0.2 µm filtered solution in 20 mM PB, pH 7.4, 150 mM NaCl. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
| Gene ID | 20299 |
|---|---|
| Other Names | C-C motif chemokine 22, Activated B and dendritic cell-derived, CC chemokine ABCD-1, Small-inducible cytokine A22, Ccl22, Abcd1, Scya22 |
| Target Background | Macrophage-Derived/CCL22 Chemokine (MDC) , also known as stimulated T cell chemotactic protein (STCP1), is a CC chemokine initially isolated from clones of monocytederived macrophages. CCL22 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. CCL22 shows chemotactic activity for natural killer cells, chronically activated T lymphocytes, monocytes and dendritic cells. CCL22 has mild chemotactic activity for primary activated T lymphocytes and no chemoattractant activity for neutrophils, eosinophils or resting T lymphocytes. CCL22 may also be involved in certain aspects of activated T lymphocyte physiology, such astrafficking activated T lymphocytes to inflammatory sites. CCL22 interacts with the cell surface chemokine receptor CCR4. |
| Name | Ccl22 |
|---|---|
| Synonyms | Abcd1, Scya22 |
| Function | Chemotactic for activated T-lymphocytes. May play an important role in the collaboration of dendritic cells and B- lymphocytes with T-cells in immune responses. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed by activated splenic B-lymphocytes and dendritic cells. Low expression in lung, thymocytes, lymph node, and unstimulated splenic cells |
Research Areas
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Cat# PVGS1119
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