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Thymosin β4
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P62328 |
|---|---|
| Species | Human |
| Sequence | Ser2-Ser44 |
| Purity | > 97% as analyzed by SDS-PAGE > 97% as analyzed by HPLC |
| Endotoxin Level | < 1 EU/ µg of protein by LAL method |
| Biological Activity | Fully biologically active when compared to standard. The biological activity determined by its ability to produce a protective effect against hydrogen peroxide in primary lung fibroblasts is in a concentration range of 0.5-10.0 µg/ml. |
| Expression System | E. coli |
| Theoretical Molecular Weight | 4.9 kDa |
| Formulation | Lyophilized from a 0.2 µm filtered solution in 20 mM PB, pH 7.4. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
| Gene ID | 7114 |
|---|---|
| Other Names | Thymosin beta-4, T beta-4, Fx, Hemoregulatory peptide AcSDKP, Ac-Ser-Asp-Lys-Pro, N-acetyl-SDKP, AcSDKP, Seraspenide, TMSB4X, TB4X, THYB4, TMSB4 |
| Target Background | Thymosin Beta 4 is a naturally occurring peptide. It is found in high concentrations in blood platelets, wound fluid and other tissues in the body. Tβ4 is not a growth factor; rather, it is a major actin regulating peptide. The thymosin beta-4 peptide, if used after a heart attack, might reactivate cardiac progenitor cells to repair damaged heart tissue. |
| Name | TMSB4X |
|---|---|
| Synonyms | TB4X, THYB4, TMSB4 |
| Function | Plays an important role in the organization of the cytoskeleton (PubMed:10848969, PubMed:1999398). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed:10848969, PubMed:1999398). |
| Cellular Location | Cytoplasm, cytoskeleton |
| Tissue Location | Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells |
Research Areas
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Cat# PVGS1159
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