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NT-4
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q80VU4 |
|---|---|
| Species | Mouse |
| Sequence | Gly80-Ala209, expressed with an N-terminal Met |
| Purity | > 95% as analyzed by SDS-PAGE |
| Endotoxin Level | < 0.2 EU/ µg of protein by gel clotting method |
| Biological Activity | ED50 < 1.0 µg/ml, measured by a cell proliferation assay using C6 cells, corresponding to a specific activity of > 1.0 × 103 units/mg. |
| Expression System | E. coli |
| Formulation | Lyophilized after extensive dialysis against 50 mM acetic acid. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in 50 mM acetic acid or ddH₂O up to 100 µg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
| Gene ID | 78405 |
|---|---|
| Other Names | Neurotrophin-4, NT-4, Neurotrophin-5, NT-5, Neutrophic factor 4, Ntf4, Ntf5 |
| Target Background | Neurotrophin-4 (NT-4), also known as NT-5, is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3. Human NT-4 shares 48 - 52% aa sequence identity with human β-NGF, BDNF, and NT-3. Neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds. NT-4 is expressed highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. NT-4 binds and induces receptor dimerization and activation of TrkB. NT-4 can signal through TrkB receptors and promotes the survival of peripheral sensory sympathetic neurons. |
| Name | Ntf4 |
|---|---|
| Synonyms | Ntf5 |
| Function | Target-derived survival factor for peripheral sensory sympathetic neurons (By similarity). May promote ameloblast differentiation and subsequent reduction in proliferation of ameloblasts (PubMed:27015268). |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:P34130}. |
Research Areas
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$ 2,839.00
$ 101.00
$ 372.00
Cat# PVGS1326
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