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GRO-β/CINC-3/CXCL2
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P30348 |
|---|---|
| Species | Rat |
| Sequence | Ser32-Asn100 |
| Purity | > 95% as analyzed by SDS-PAGE |
| Endotoxin Level | < 0.2 EU/ µg of protein by gel clotting method |
| Biological Activity | The EC50 value of Rat GRO-β/CINC-3/CXCL2 on Ca2+ mobilization assay in CHO-K1/Gα15/rCXCR2 cells (human Gα15 and rat CXCR2 stably expressed in CHO-K1 cells) is less than 10.0 ng/ml. |
| Expression System | E. coli |
| Formulation | Lyophilized after extensive dialysis against PBS. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 µg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
| Gene ID | 114105 |
|---|---|
| Other Names | C-X-C motif chemokine 2, Cytokine-induced neutrophil chemoattractant 3, CINC-3, Macrophage inflammatory protein 2, MIP2, Cxcl2, Cinc3, Mip-2, Mip2, Scyb2 |
| Target Background | Chemokine (C-X-C motif) ligand 2(CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 shares 90% amino acid sequence with CXCL1/GROα. The GRO proteins are chemotactic for neutrophils and basophils and can activate them through their CXCR1 or CXCR2 receptors. |
| Name | Cxcl2 |
|---|---|
| Synonyms | Cinc3, Mip-2, Mip2, Scyb2 |
| Function | Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. Contributes to neutrophil activation during inflammation. |
| Cellular Location | Secreted. |
| Tissue Location | At least expressed in the lung and trachea. |
Research Areas
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Cat# PVGS1448
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