IL-17 RD
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8JZL1-1 |
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Species | Mouse |
Sequence | Gly28-Arg299 |
Purity | > 95% as analyzed by SDS-PAGE > 95% as analyzed by HPLC |
Endotoxin Level | < 0.2 EU/ µg of protein by gel clotting method |
Biological Activity | ED50 < 5.0 µg /ml, measured in a cell proliferation assay using wt MEF cells. |
Expression System | CHO |
Formulation | Lyophilized from a 0.2 µm filtered solution in PBS. |
Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 µg/ml. |
Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
Target Background | Interleukin-17 receptor D (IL-17RD) , also known as similar expression to the fibroblast growth factor receptor (SEF), is a member of the interleukin-17 receptor family. Studies indicate that IL-17RD interacts with IL-17R to facilitate IL-17 signaling. Additionally, IL-17RD may play an important role in preventing certain types of cancer. Studies suggest that IL-17D acts as a feedback inhibitor of fibroblast growth factor-mediated MAPK signaling and ERK activation. Studies indicate that IL-17D can bind to MEK/ERK complexes preventing nuclear ERK translocation and subsequent cell proliferation. |
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