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C-C motif chemokine 25
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O35903 |
|---|---|
| Sequence | MQGAFEDCCL GYQHRIKWNV LRHARNYHQQ EVSGSCNLRA VRFYFRQKVV CGNPEDMNVK RAMRILTARK RLVHWKSASD SQTERKKSNH MKSKVENPNS TSVRSATLGH PRMVMMPRKT NN |
| Purity | > 98% as analyzed by SDS-PAGE. |
| Endotoxin Level | < 0.2 EU/ µg, determined by LAL method. |
| Formulation | Lyophilized after extensive dialysis against PBS. |
| Reconstitution | Reconstituted in ddH2O or PBS at 100 µg/ml. |
| Gene ID | 20300 |
|---|---|
| Other Names | C-C motif chemokine 25, Chemokine TECK, Small-inducible cytokine A25, Thymus-expressed chemokine, Ccl25, Scya25, Teck |
| Target Background | Chemokine (C-C motif) ligand 25 (CCL25) is a small cytokine belonging to the CC chemokine family that is also known as TECK (Thymus-Expressed Chemokine). It plays a role in the development of T cells and has been shown to be chemotactic for activated macrophages, dendritic cells and thymocytes. Mouse CCL25 cDNA encodes a 144 amino acid residue precursor protein with a 23 amino acid residue signal peptide that is cleaved to yield a 121 residue mature protein. The gene for mouse CCL25 has been mapped to chromosome 8 rather than chromosome 11 where many mouse CC chemokines are clustered. Mouse CCL25 shares 49% amino acid sequence identity to with human CCL25. Recombinant Mouse TECK/CCL25 produced in E. coli is a single non-glycosylated polypeptide chain containing 122 amino acids. A fully biologically active molecule, rmTECK/CCL25 has a molecular mass of 14.3 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at . |
| Name | Ccl25 |
|---|---|
| Synonyms | Scya25, Teck |
| Function | Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
| Cellular Location | Secreted. |
| Tissue Location | Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine |
Research Areas
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Cat# PVGS1462
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