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IL-6

     
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Product Information
Primary Accession P26892
Species Bovine
Sequence Gly30-Lys208
Purity ≥ 95% as analyzed by SDS-PAGE
Endotoxin Level < 0.2 EU/ µg of protein by gel clotting method
Expression System P. pastoris
Theoretical Molecular Weight 20.7 kDa
Formulation Lyophilized from a 0.2 µm filtered solution in PBS, pH 7.4
Reconstitution Before opening, centrifuge the vial briefly to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O up to 100 µg/ml
Storage & Stability Upon receiving, this product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable up to 1 week at 4 °C or up to 3 months at -20 °C or below. Avoid repeated freeze-thaw cycles.
Additional Information
Gene ID 280826
Other Names Interleukin-6, IL-6, IL6
Target Background Interleukin-6 (IL-6), also known as BSF-2, CDF and IFNB2, is a pleiotropic cytokine. IL-6 participates in both pro-inflammatory and anti-inflammatory responses. IL-6 is produced mainly by T cells, macrophages and muscle cells. It stimulates B cell differentiation and antibody production, and cell differentiation.
Protein Information
Name IL6
Function Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane- bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
Cellular Location Secreted {ECO:0000250|UniProtKB:P05231}.
Research Areas
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Cat# PVGS1756
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