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Bax BH3 peptide (55 - 74), wild type

Synthetic Peptide

     
  • SPECIFICATION
  • CITATIONS: 1
  • PROTOCOLS
  • BACKGROUND
Product Information
Primary Accession O02703
Other Accession Q07812
Sequence NH2-STKKLSECLKRIGDELDSNM-COOH
Additional Information
Gene ID 280730
Other Names Apoptosis regulator BAX, BAX
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAX
Function Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Cellular Location [Isoform Alpha]: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q07812}; Single-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q07812}. Nucleus {ECO:0000250|UniProtKB:Q07812}. Note=Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane (By similarity) {ECO:0000250|UniProtKB:Q07812} [Isoform Gamma]: Cytoplasm.
Research Areas
Citations ( 0 )
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$ 277.78
Cat# SP2426a
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Availability: 2-3 weeks
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