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Calcitonin Gene Related Peptide (CGRP) Antibody
Mouse monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| ICC |
|---|---|
| Primary Accession | P01256 |
| Reactivity | Human, Rat |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2a |
| Clone Names | 4901 |
| Calculated MW | 13948 Da |
| Gene ID | 24241 |
|---|---|
| Gene Name | CALCA |
| Other Names | Calcitonin gene-related peptide 1, Alpha-type CGRP, Calcitonin gene-related peptide I, CGRP-I, Calca, Calc |
| Target/Specificity | Purified rat alpha-CGRP. |
| Dilution | ICC~~1:50-1:100 |
| Format | Protein G purified |
| Antibody Specificity | Specific for Calcitonin Gene Related Peptide. Also recognizes rat beta-CGRP and human alpha-CGRP (10-fold less sensitivity compared to rat alpha-CGRP). Suggested positive controls are dorsal root ganglia, pancreas and gut. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Calcitonin Gene Related Peptide (CGRP) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Shipping | Blue Ice |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calcitonin Gene Related Peptide [CGRP] is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known (Brain et al.,1985). CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain. This effect was found to be antagonized by capsazepine. CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches (Edvinsson L., 2003). CGRP antibodies have been used successfully in immunoneutralization (Wong et al., 1993)
References
Brain SD, Williams TJ, Tippins JR, Morris HR, MacIntyre I (1985) Calcitonin gene related peptide is a potent vasodilator. Nature 313 (5997): 54-6
Edvinsson L (2003) New therapeutic target in primary headaches—blocking the CGRP receptor. Expert Opin Ther Targets.7(3):377-83
Wong HC, Tache’ Y, Lloud KCK, Yang H, Sternini C, Holzer P, Walsh JH (1993) Monoclonal antibody to rat alpha-CGRP: production, charactrization, and in vivo immunoneutralization activity. Hybridoma. 12:93-106.
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