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S6A12 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | P48065 |
| Other Accession | NP_003035.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 69368 Da |
| Antigen Region | 9-38 aa |
| Gene ID | 6539 |
|---|---|
| Other Names | Sodium- and chloride-dependent betaine transporter, BGT-1, Na(+)/Cl(-) betaine/GABA transporter, Solute carrier family 6 member 12, SLC6A12 |
| Target/Specificity | This S6A12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human S6A12. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | S6A12 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC6A12 (HGNC:11045) |
|---|---|
| Function | Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (PubMed:7589472). May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Probably also involved in renal and hepatic osmotic regulation (By similarity). |
| Cellular Location | Basolateral cell membrane {ECO:0000250|UniProtKB:P31651}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:P31651}; Multi-pass membrane protein. Note=In kidney, locates in basolateral membranes of renal medulla. In liver, locates in hepatocytes cell membrane. {ECO:0000250|UniProtKB:P31651} |
| Tissue Location | Expressed in kidney, liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.
References
Pasaje, C.F., et al. Ann. Hum. Genet. 74(4):326-334(2010) Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010) Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) : Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009) Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :
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