CCDC8 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q9H0W5 |
Other Accession | NP_114429.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 59374 Da |
Antigen Region | 390-418 aa |
Gene ID | 83987 |
---|---|
Other Names | Coiled-coil domain-containing protein 8, CCDC8 |
Target/Specificity | This CCDC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390-418 amino acids from the C-terminal region of human CCDC8. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CCDC8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CCDC8 |
---|---|
Function | Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695). |
Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
Tissue Location | Widely expressed with low levels in spleen, skeletal muscle, small intestine, kidney and liver |
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Provided below are standard protocols that you may find useful for product applications.
References
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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