RNH2C Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, WB, E |
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Primary Accession | Q8TDP1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 17840 Da |
Antigen Region | 80-108 aa |
Gene ID | 84153 |
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Other Names | Ribonuclease H2 subunit C, RNase H2 subunit C, Aicardi-Goutieres syndrome 3 protein, AGS3, RNase H1 small subunit, Ribonuclease HI subunit C, RNASEH2C, AYP1 |
Target/Specificity | This RNH2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-108 amino acids from the Central region of human RNH2C. |
Dilution | WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | RNH2C Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RNASEH2C |
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Synonyms | AYP1 |
Function | Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. |
Cellular Location | Nucleus. |
Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
RNH2C encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes.
References
Chon,H., et.al., Nucleic Acids Res. 37 (1), 96-110 (2009)
Rice,G., et.al., Am. J. Hum. Genet. 81 (4), 713-725 (2007)
Crow,Y.J., et.al., Nat. Genet. 38 (8), 910-916 (2006)
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