|Application ||FC, WB, E|
|Calculated MW||17840 Da|
|Antigen Region||80-108 aa|
|Other Names||Ribonuclease H2 subunit C, RNase H2 subunit C, Aicardi-Goutieres syndrome 3 protein, AGS3, RNase H1 small subunit, Ribonuclease HI subunit C, RNASEH2C, AYP1|
|Target/Specificity||This RNH2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-108 amino acids from the Central region of human RNH2C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RNH2C Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|
|Tissue Location||Widely expressed..|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
RNH2C encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes.
Chon,H., et.al., Nucleic Acids Res. 37 (1), 96-110 (2009)
Rice,G., et.al., Am. J. Hum. Genet. 81 (4), 713-725 (2007)
Crow,Y.J., et.al., Nat. Genet. 38 (8), 910-916 (2006)
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