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Bassoon Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q9UPA5 |
| Other Accession | NP_003449.2 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Clonality | Polyclonal |
| Description | Rabbit Anti-Human Bassoon Polyclonal |
| Target/Specificity | Detects ~420kDa. Multiple isoforms can be detected. |
| Other Names | BSN Antibody, ZNF231 Antibody, Neuronal double zine finger protein Antibody |
| Immunogen | NM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein |
| Purification | Protein A Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SPC-198 was sufficient for detection of Bassoon in 10 µg of rat brain tissue lysate by colorimetric immunoblot analysis using goat ant rabbit IgG:HRP as the secondary antibody. |
| Cellular Localization | Cytoplasm | Cell Junction | Synapse |
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Provided below are standard protocols that you may find useful for product applications.
Background
Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntington, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to co-localize with GABA (A) and glutamate (GluR1) receptors (1).
References
1. Anna Dondzillo et al., (2010) J. Comp Neur, 518(7): 1008–1029.
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