|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Description||Rabbit Anti-Human Bassoon Polyclonal|
|Target/Specificity||Detects ~420kDa. Multiple isoforms can be detected.|
|Other Names||BSN Antibody, ZNF231 Antibody, Neuronal double zine finger protein Antibody|
|Immunogen||NM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein|
|Purification||Protein A Purified|
|Storage Buffer||PBS pH7.4, 50% glycerol, 0.09% sodium azide|
|Shipping Temperature||Blue Ice or 4ºC|
|Certificate of Analysis||1 µg/ml of SPC-198 was sufficient for detection of Bassoon in 10 µg of rat brain tissue lysate by colorimetric immunoblot analysis using goat ant rabbit IgG:HRP as the secondary antibody.|
|Cellular Localization||Cytoplasm | Cell Junction | Synapse|
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Provided below are standard protocols that you may find useful for product applications.
Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntington, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to co-localize with GABA (A) and glutamate (GluR1) receptors (1).
1. Anna Dondzillo et al., (2010) J. Comp Neur, 518(7): 1008–1029.
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