Bassoon Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC |
---|---|
Primary Accession | Q9UPA5 |
Other Accession | NP_003449.2 |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Clonality | Polyclonal |
Description | Rabbit Anti-Human Bassoon Polyclonal |
Target/Specificity | Detects ~420kDa. Multiple isoforms can be detected. |
Other Names | BSN Antibody, ZNF231 Antibody, Neuronal double zine finger protein Antibody |
Immunogen | NM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein |
Purification | Protein A Purified |
Storage | -20ºC |
Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
Shipping Temperature | Blue Ice or 4ºC |
Certificate of Analysis | 1 µg/ml of SPC-198 was sufficient for detection of Bassoon in 10 µg of rat brain tissue lysate by colorimetric immunoblot analysis using goat ant rabbit IgG:HRP as the secondary antibody. |
Cellular Localization | Cytoplasm | Cell Junction | Synapse |
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Provided below are standard protocols that you may find useful for product applications.
Background
Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntington, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to co-localize with GABA (A) and glutamate (GluR1) receptors (1).
References
1. Anna Dondzillo et al., (2010) J. Comp Neur, 518(7): 1008–1029.
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