|Other Names||E3 ubiquitin-protein ligase LRSAM1, 632-, Leucine-rich repeat and sterile alpha motif-containing protein 1, Tsg101-associated ligase, hTAL, LRSAM1, TAL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria- associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098).|
|Cellular Location||Cytoplasm. Note=Displays a punctuate distribution and localizes to a submembranal ring (PubMed:15256501). Localizes to intracellular bacterial pathogens (PubMed:23245322).|
|Tissue Location||Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue|
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Provided below are standard protocols that you may find useful for product applications.
LRSAM1 is a multifunctional RING finger protein thatselectively regulates cell adhesion molecules, has ubiquitin ligaseactivity, and plays a role in receptor endocytosis and viralbudding (Li et al., 2003 [PubMed 14635195]; Amit et al., 2004[PubMed 15256501]).
Markson, G., et al. Genome Res. 19(10):1905-1911(2009)van Wijk, S.J., et al. Mol. Syst. Biol. 5, 295 (2009) :McDonald, B., et al. Mol. Biol. Cell 19(2):754-763(2008)Amit, I., et al. Genes Dev. 18(14):1737-1752(2004)Li, B., et al. J. Cell. Biochem. 90(6):1224-1241(2003)
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