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FAM35A Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q86V20
Clone Names 81006144
Peptide ID 81006144
Additional Information
Gene ID 54537
Other Names Protein FAM35A, FAM35A
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13091a was selected from the N-term region of FAM35A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SHLD2 {ECO:0000303|PubMed:29656893, ECO:0000312|HGNC:HGNC:28773}
Function Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ- dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893).
Cellular Location Nucleus. Chromosome Note=Localizes to nuclear foci in response to DNA damage
Research Areas
Citations (0)

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Background

The specific function of this protein remains unknown.

References

Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Deloukas, P., et al. Nature 429(6990):375-381(2004)

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Cat# BP13091a
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