Anti-FAM35A/B Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q86V20 |
Other Accession | A6NDK8 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 93705 Da |
Gene ID | 54537 |
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Other Names | FAM35A; Protein FAM35A; FAM35B; Protein FAM35B |
Target/Specificity | Recognizes endogenous levels of FAM35A/B protein. |
Dilution | WB~~1/500 - 1/1000 |
Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | SHLD2 {ECO:0000303|PubMed:29656893, ECO:0000312|HGNC:HGNC:28773} |
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Function | Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). |
Cellular Location | Nucleus. Chromosome. Note=Localizes to nuclear foci in response to DNA damage. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Rabbit polyclonal antibody to FAM35A/B
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