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Anti-FAM35A/B Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q86V20 |
| Other Accession | A6NDK8 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 93705 Da |
| Gene ID | 54537 |
|---|---|
| Other Names | FAM35A; Protein FAM35A; FAM35B; Protein FAM35B |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human FAM35A/B. The exact sequence is proprietary. |
| Dilution | WB~~1/500 - 1/1000 |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | SHLD2 {ECO:0000303|PubMed:29656893, ECO:0000312|HGNC:HGNC:28773} |
|---|---|
| Function | Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). |
| Cellular Location | Nucleus. Chromosome. Note=Localizes to nuclear foci in response to DNA damage. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Rabbit polyclonal antibody to FAM35A/B
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$ 385.00
Cat# AP53970
Ordering Information
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