FAM35A Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IHC-F, IF, ICC |
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Primary Accession | Q86V20 |
Reactivity | Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 93705 Da |
Gene ID | 54537 |
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Other Names | Shieldin complex subunit 2 {ECO:0000312|HGNC:HGNC:28773}, Protein FAM35A, RINN1-REV7-interacting novel NHEJ regulator 2, Shield complex subunit 2, SHLD2 {ECO:0000303|PubMed:29656893, ECO:0000312|HGNC:HGNC:28773} |
Dilution | WB=1:500-2000,Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | SHLD2 {ECO:0000303|PubMed:29656893, ECO:0000312|HGNC:HGNC:28773} |
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Function | Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). |
Cellular Location | Nucleus. Chromosome. Note=Localizes to nuclear foci in response to DNA damage. |
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