|Other Names||N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming), Acylase III, Aminoacylase-3, ACY-3, Aspartoacylase-2, Hepatitis C virus core-binding protein 1, HCBP1, HCV core-binding protein 1, ACY3, ASPA2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8715c was selected from the Center region of human ACY3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity).|
|Cellular Location||Apical cell membrane; Peripheral membrane protein. Cytoplasm Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm|
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Provided below are standard protocols that you may find useful for product applications.
ACY3 belongs to the aspA/astE family. Aspartoacylase subfamily. Catalytic activity: N-acyl-L-aspartate + H(2)O = a carboxylate + L-aspartate
Chen,Y.R., et.al., J. Gastroenterol. Hepatol. 24 (7), 1300-1304 (2009)Pushkin,A., et.al., Am. J. Physiol., Cell Physiol. 286 (4), C848-C856 (2004)
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