|Other Names||Ceroid-lipofuscinosis neuronal protein 5, Protein CLN5, CLN5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8914a was selected from the N-term region of human CLN5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane (PubMed:22431521).|
|Cellular Location||[Ceroid-lipofuscinosis neuronal protein 5, secreted form]: Lysosome|
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Provided below are standard protocols that you may find useful for product applications.
CLN5 responsible likely is involved in the degradation of post-translationally modified proteins in lysosomes.
Savukoski,M., et.al., Am. J. Hum. Genet. 55 (4), 695-701 (1994) Mole,S.E., et.al., Hum. Mutat. 14 (3), 199-215 (1999)
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