CLN5 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O75503 |
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Clone Names | 90909025 |
Gene ID | 1203 |
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Other Names | Ceroid-lipofuscinosis neuronal protein 5, Protein CLN5, CLN5 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8914a was selected from the N-term region of human CLN5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CLN5 |
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Synonyms | BMPS {ECO:0000303|PubMed:37708259} |
Function | [Bis(monoacylglycero)phosphate synthase CLN5, secreted form]: Catalyzes the synthesis of bis(monoacylglycero)phosphate (BMP) via transacylation of 2 molecules of lysophosphatidylglycerol (LPG) (PubMed:37708259). BMP also known as lysobisphosphatidic acid plays a key role in the formation of intraluminal vesicles and in maintaining intracellular cholesterol homeostasis (PubMed:37708259). Can use only LPG as the exclusive lysophospholipid acyl donor for base exchange and displays BMP synthase activity towards various LPGs (LPG 14:0, LPG 16:0, LPG 18:0, LPG 18:1) with a higher preference for longer chain lengths (PubMed:37708259). Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane (PubMed:22431521). Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane (PubMed:22431521). |
Cellular Location | [Bis(monoacylglycero)phosphate synthase CLN5, secreted form]: Lysosome |
Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CLN5 responsible likely is involved in the degradation of post-translationally modified proteins in lysosomes.
References
Savukoski,M., et.al., Am. J. Hum. Genet. 55 (4), 695-701 (1994) Mole,S.E., et.al., Hum. Mutat. 14 (3), 199-215 (1999)
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